Central Nervous System
In response to recent advances in MRI technology, we have developed a novel probe for real-time mapping of acetylcholine in the brain. Enzymatic hydrolysis of acetylcholine causes deprotonation of the co-localized contrast agent, altering the measurable relaxivities of the sensor to generate a readable image of the choline pathway.
The Clark Lab
Arizona State University
School of Biological and Health Systems Engineering
ASU Engineering Center, Tempe, AZ 85281